Association nuclear genome mutations with myocardial infarction

Abstract

Objective. This review is dedicated to a description of nuclear genome mutations associated with increased risk of
myocardial infarction (MI).
Materials and Methods. Scientific articles from NCBI base (ncbi.nlm.nih.gov) were used to work on this review.
Results and discussion. A number of data from domestic and foreign literature was analyzed. It was shown that in
the presence of these mutations, as a rule, pathologies in cardiovascular, muscular and nervous systems occur, which
are usually characterized by a late manifestation of clinical symptoms.
Conclusion. The large sample analysis of patients and a description of hundreds of genealogies, information about
the relationship between genotype and phenotype, structure and frequency of mutations in myocardial infarction let
us reveal a number of important mutations in genes regulating the metabolism of lipids and carbohydrates which
are responsible for the functional activity of the enzymes. The mutations cited in the article are classified by their
localization in genes of human nuclear genome