The values of cardio-ankle vascular index in patients with impaired glucose metabolism according to research «ECVE-RF» in the Kemerovo region

Abstract

Objective. To identify the prevalence of abnormal cardio-ankle vascular index (CAVI) in patients with impaired glucose metabolism (IGM) and factors correlated with its value.
Patients and methods. The study was held on within the cross-sectional multicenter trail «Epidemiology of Cardiovascular Diseases and Their Risk Factors in the Russian Federation» (ECVE-RF) conducted from March to October 2013. The random population sample of adult males and females aged 25–64 years from Kemerovo region with particular investigation of CAVI. Each participant has given written informed consent. Standard research protocol ECVE-RF extended by further study of peripheral arterial stiffness on the VaSeraVS-1000 (Fukuda Denshi, Japan) with automatically measured CAVI.
From a sample of 1619 people participants with IGM were isolated: diabetes mellitus (DM) type 1 and 2, impaired fasting glucose (IFG), impaired glucose tolerance (IGT) – a total of 318 people. Two patients with type 1 diabetes, 29 patients with values of ankle-brachial index (ABI) of less than 0.9 (to avoid distortion values CAVI) and 5 patients in whom CAVI has not been studied were excluded from analysis. Thus, the final sample included 282 patients with type 2 diabetes and prediabetes (IFG, IGT), they were divided into two groups: I (n=41) patients with CAVI≥9.0 (pathological CAVI), II (n=241) patients with CAVI <9.0 (normal CAVI).
Results. Pathological CAVI was detected in 14.5% of sample patients with IGM. There was a positive correlation of CAVI value and age (r=0.450; p<0.001), smoking history (r=0.494; p<0.001), increase in systolic and diastolic blood pressure (r=0.303 and r=0.309, respectively, p<0.001), visceral obesity (r=0.123; p=0.031), total cholesterol level (r=0.136; p=0.019), LDL cholesterol (r=0.153; p=0.010) and glucose (r=0.135; p=0.023) levels, negative – with a body mass index (r=-0.121; p=0.042), and glomerular filtration rate CKDEPI (r=-0,365; p<0.001).
Conclusions. The measurement of CAVI in patients with impaired glucose metabolism allows revealing patients with an increased risk of cardiovascular complications.