Oxidized low-density lipoproteins and antibodies against oxidized low-density lipoproteins in patients with coronary atherosclerosis and healthy individuals

Abstract

Purpose. To determine the role of oxidized low-density lipoproteins (OxLDL) and antibodies against oxidized lowdensity lipoproteins (anti-OxLDL) in immuno-inflammatory process in patients (pts) with coronary atherosclerosis.
Methods. Three groups of male pts aged from 28 to 68 years were included in the study: healthy pts group without coronary heart disease (n=10); a group with initial coronary arteries' atherosclerotic lesions (<50%, n=20) and group with angiographically documented severe coronary stenosis (>50%, n=50). Serum OxLDL and anti-OxLDL were identified by immune-enzyme analysis using MDA-oxLDL and OLAB IgG Biomedica commercial kits.
Results. There were not significant differences in OxLDL levels between these groups of pts (p>0.3), but anti-OxLDL titers in healthy pts group were significantly higher compared to the pts with severe coronary stenosis (p=0.03). SYNTAX Score was used to assess the severity of coronary lesions in group of pts with severe coronary atherosclerosis. The anti-OxLDL titers was significantly higher in pts with SYNTAX index below the average median (p=0.03).
Conclusion. We didn't found significant evidence of association between OxLDL levels and coronary atherosclerosis in our clinical study. However, anti-OxLDL titers in healthy pts group were higher than in pts with severe coronary atherosclerosis. Among the pts with severe coronary atherosclerosis, a higher level of anti-OxLDL was observed in patients with a lower coronary lesions severity.