The association of genetic risk factors of atherosclerosis with traditional risk factors of atherosclerosis in patients with coronary heart disease living in highlands (at the example of Karachay-Cherkessia

Abstract

Objective. To study significance of the heteroplasmy of the mitochondrial genome as the risk factor of atherosclerosis and its association with traditional risk factors in patients with coronary heart disease (CHD) living in highlands.
Materials and methods. 112 patients who came to see a doctor to the polyclinic of central regional hospital of Malokarachaevsky region of Karachay-Cherkessia were included in the research. As a result the examined people were divided into 2 groups. The first group included 77 patients with coronary heart disease, 60 men (78%) and 17 women (22%). The second group included 35 patients without CHD according to the examination results, 28 men (80%) and 7 women (20%). The average age of patients was 61.5±2.2 years in the first group and 54.1±2.8 years in the second. The determination of behavioral risk factors and clinical and laboratory examination were made.
Results. Тhe study allowed to find out that there wasn’t any association between mutations of the mitochondrial genome and the serum lipid profile. Smoking also didn’t increase the count of mutations. There was not found any association between the heteroplasmy of mitochondrial genome and other traditional risk factors, such as central obesity and diabetes. Arterial hypertension in anamnesis and systolic blood pressure had negative correlation with the level of heteroplasmy of G15059A mutation. The study also detected a negative correlation between the coronary heart disease and G14846A and G13513A mutations presence.
Conclusions. According to our data G14846A and G13513A mutations may have the antiatherogenic features. A negative correlation between the level of heteroplasmy of G15059A mutation and such atherosclerotic risk factor as arterial hypertension, may also indicate its indirect antiatherogenic influence.