Assessment of genetically complex dependence on the apolipoprotein A+I, B, and C+III, E and lipoprotein (a) in patients with hypertriglyceridemia
Keywords:
Hypertriglyceridemia, apolipoprotein C-III, apolipoprotein E, lipoprotein (a)Abstract
Objective. The objective of the work was to evaluate importance of some genetic-related parameters determination such as serum apolipoproteins (apo) A-I, B, C-III, E, and Lp(a) in patients with hypertriglyceridemia \ (HTG) who were consulted by a lipidologist.
Patients and methods. The study group consisted of 96 patients (48 men and 48 women) from 17 to 70 years old, with serum triglycerides (TG) exceeding 2,3 mmol/l. Fasting plasma TG, cholesterol, apo A-I, B, C-III, E, and Lp(a) were measured. Lipid electrophoresis was also performed.
Results. We found the significant correlations of serum TG levels with apo E and C-III, and apo E with apo C-III in patients with HTG that points out the receptor defect of VLDL uptake by some cells that is one of some causes developing HTG. Apo B level was higher in patients with type IIb hyperlipidemia in comparison to types III, IV and V. As to apo A-I and Lp(a) levels, we have found no difference between patients with moderate and severe HTG. The elevated levels of serum apo E and C-III were determined in 68,8 % and 76 % patients, accordingly.
Conclusion. The evaluation of genetic-related parameters of serum apo C-III and apo E is an additional diagnostic tool for the identification of primary HTG patients.
