Proprotein convertase subtilisin / keksin type 9 (PCSK9) + control the expression of low density lipoprotein receptor

Abstract

New data became available during last decade about the regulation of expression of hepatic low density lipoprotein
receptor (LDL-R) which supplies clearance of LDL particles from the blood. Proprotein convertase subtilisin kexin 9
(PCSK9) was identified and it has been shown that this molecule plays a key role in degradation of LDL-Rs. This leads
to a lower uptake and further catabolism of circulating LDL, as result the concentration of LDL in the serum raises.
Current review is devoted to the discovery of PCSK9, its role in LDL-R degradation, regulation of PCSK9 expression
and to its physiological role.