Роль дисфункции митохондрий в патогенезе воспалительных заболеваний и атеросклероза

T. V. Tolstik; T. V. Kirichenko; A. I. Bogatyreva; Yu. V. Markina; A. M. Markin; S. G. Kozlov

doi:10.34687/2219-8202.JAD.2023.03.0002

Authors

T. V. Tolstik Petrovsky National Research Center of Surgery
T. V. Kirichenko Petrovsky National Research Center of Surgery
A. I. Bogatyreva Petrovsky National Research Center of Surgery
Yu. V. Markina ФГБНУ "РНЦХ им. академика Б.В. Петровского"
A. M. Markin Рeoples’ Friendship University of Russia
S. G. Kozlov Chazov National Medical Research Center of Cardiology

DOI:

https://doi.org/10.34687/2219-8202.JAD.2023.03.0002

Abstract

Currently, mitochondrial dysfunction is considered as one of the key factors in the occurrence and progression of metabolic and inflammatory diseases, and, in particular, in the pathogenesis of atherosclerosis. Mitochondria form a homogeneous network in the cell, in which the processes of fission, fusion and mitophagy normally occur continuously. The imbalance of these processes leads to mitochondrial dysfunction and the development of pathological conditions. Metabolic changes in mitochondria affect various biological processes in the organism, in particular, they control the formation and differentiation of monocytes, the key cells in the pathogenesis of inflammation. The molecular mechanisms underlying the regulation of mitochondrial dynamics in monocytes are not well understood. In this review, we tried to consider in detail the processes occurring in mitochondria in normal and pathological conditions, as well as to discuss the possibilities of developing new diagnostic and therapeutic strategies for diseases in which pathogenesis the mitochondrial dysfunction plays an important role.

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