Excessive formation of advanced glycation end-products as a possible cause of increased risk of restenosis after coronary stenting in patients with diabetes mellitus

Abstract

Patients with diabetes mellitus are at increased risk of restenosis after coronary artery stenting. Chronic hyperglycemia is associated with advanced glycation end products excessive production. There are data that in-stent restenosis in patients with diabetes mellitus may be related to plasma level of advanced glycation end products. One of the reasons for this is that protein glycation by alteration of protein structure adversely affects their function. Another cause may be due to the interaction between advanced glycation end products and membrane-bound receptor for advanced glycation end-products. Experimental data indicate that blockade of receptor for advanced glycation end-products with soluble receptor for advanced glycation end-products resulted in significantly decreased of neointimal expansion after arterial injury.