Study of associations of blood fatty acid spectrum with lipid profile in men of Novosibirsk (ESSE-RF3 in the Novosibirsk region)
DOI:
https://doi.org/10.34687/2219-8202.JAD.2024.01.0001Keywords:
fatty acids, lipid profile, blood, populationAbstract
Aim. To study the content of fatty acids in blood plasma, as well as their associations with the lipid profile in Novosibirsk men (ESSE-RF3 in the Novosibirsk region).
Material and methods. Within the framework of the multicenter single-stage epidemiological study ESSE-RF3 in the Novosibirsk region, 1200 residents of Novosibirsk aged 35-74 years were examined. The present study included 500 men with an average age of 54.63±11.34 years. The serum levels of total cholesterol, low-density lipoproteins (LDL-C) and high-density lipoproteins (HDL-C), triglycerides (TG) were studied. The determination of cholesterol not associated with high-density lipoproteins (non-HDL) was calculated using the formula. The fatty acid spectrum of blood was determined in blood plasma, including omega-3,-6,-9 fatty acids: alpha-linolenic (C 18:3), eicosapentaenoic (C 20:5), docosahexaenoic (C 22:6), linoleic (C 18:2), gamma-linolenic (C 18:3), digomo-gamma-linolenic (C 20:3), arachidonic (C 20:4), docosatetraenoic (C 22:4), docosapentaenoic (C 22:5), palmitoleic (C 16:1), oleic (C 18:1), mead (C 20:3), nervonic (C 24:1).
Results. In men aged 35-74 years with LDL-C ≥ 3.0 mmol/l and/or non-HDL ≥3.4 mmol/l the content of nervonic acid is 7% higher (p=0.049). In men with a TG ≥1.7 mmol/l the content of gamma-linolenic, digomo-gamma-linolenic and mead acids in blood plasma is 38% higher (p=0.001), 34% (p=0.028) and 57% (p=0.009), respectively. Correlation analysis revealed links
between the studied acids with the levels of TG-c 22:6, C 18:3, c 20:3 omega-6 and c 20:3 omega-9; with the levels of LDL-C and HC-non-HDL – c 24:1. Correlation analysis revealed links between the studied acids with the levels of TG-c 22:6, C 18:3, c 20:3 (omega-6) and c 20:3 (omega-9); with
the levels of LDL-C and non-HDL – c 24:1. The results of multivariate logistic regression analysis showed that an increase in the content of nervonic acid and a decrease in arachidonic acid in blood plasma is associated with a relative chance of having LDL-C ≥3.0 mmol/l or non-HDL
≥3.4 mmol/L. The chance of having TG ≥ 1.7 mmol/l increases with an increase in blood levels of gamma-linolenic and mead acids.
Conclusion. Thus, men aged 35-74 in Novosibirsk have significant changes in the fatty acid composition of blood plasma, which are associated with changes in the lipid profile.
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Copyright (c) 2024 В. С. Шрамко, Л. В. Щербакова, Г. И. Симонова, А. Д. Худякова, Ю. А. Баланова, А. Э. Имаева, С. А. Шальнова, Ю. И. Рагино
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