Lipoproteid subfractions in patients with various cardiovascular risk
DOI:
https://doi.org/10.34687/2219-8202.JAD.2022.01.0006Abstract
Aim. To analyze lipoproteins subfractions in subjects with various cardiovascular risk and cardiovascular disease (CVD).
Materials and methods. We included 91 patients (66 men, mean age 57±10 years; 25 women, mean age 61±11 years) with one or more atherosclerosis risk factors, with and without CVD. All patients were on hy- polipidemic therapy with statins. Lipid parameters were determined by the enzymatic method, the quanti- tative determination of lipoprotein subfractions was carried out using the Lipoprint® Quantimetrix system (USA).
Results. All patients were divided into three groups: moderate risk (group 1, n = 13), high risk (group 2, n = 12), and very high risk with CVD (group 3, n = 66). Tere were no statistically significant differences between the groups in lipids and lipoproteins subfractions, excepting small dense low-density lipoprotein
(sdLDL) particles in the group 1 and 3 (median [25%; 75%]: 0.0 [0.0; 2.0] mg/dL and 2.0 [0.0; 3.0] mg/dL, respectively, p < 0.05). We found that cardiovascular risk was positively associated with age (r = 0.325; p <0.01), the levels of subfractions of intermediate-density lipoproteins (IDL-C, r = 0.225; p = 0.032) and sdLDL (r = 0.216; p < 0.039). An inverse relationship was demonstrated with small subfractions of IDL (IDL-A, r = -0.210; p = 0.046). According to multivariate analysis only association of sdLDL with higher cardiovascular risk remained (p = 0.022).
Conclusion. Patients with high and very high cardiovascular risk have increased levels of sdLDL particles.
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Copyright (c) 2022 Е. А. Уткина, Н. В. Артемьева, М. В. Ежов, О. И. Афанасьева, С. Н. Покровский
This work is licensed under a Creative Commons Attribution 4.0 International License.