Предикторы неблагоприятного  прогноза у больных острым  коронарным синдромом без подъема  сегмента ST, перенесших чрескожное  коронарное вмешательство

A. S. Draganova; E. A. Polyakova; O. D.  Belyaeva; E. A. Bazhenova; E. V. Kulikova; T. L. Karonova; O. A. Berkovich; E. V. Shlyakhto

doi:10.34687/2219-8202.JAD.2020.03.0003

Authors

A. S. Draganova First Pavlov State Medical University of St. Petersburg, Almazov National Medical Research Centre
E. A. Polyakova First Pavlov State Medical University of St. Petersburg, Almazov National Medical Research Centre
O. D. Belyaeva First Pavlov State Medical University of St. Petersburg, Almazov National Medical Research Centre
E. A. Bazhenova First Pavlov State Medical University of St. Petersburg, Almazov National Medical Research Centre
E. V. Kulikova First Pavlov State Medical University of St. Petersburg
T. L. Karonova First Pavlov State Medical University of St. Petersburg, Almazov National Medical Research Centre
O. A. Berkovich First Pavlov State Medical University of St. Petersburg, Almazov National Medical Research Centre
E. V. Shlyakhto First Pavlov State Medical University of St. Petersburg, Almazov National Medical Research Centre

DOI:

https://doi.org/10.34687/2219-8202.JAD.2020.03.0003

Keywords:

leptin, omentin-1, microRNA-27a, the level of tissue protein omentin-1 and leptin in subcutaneous adipose tissue, acute coronary syndrome

Abstract

The aim of the study was to identify predictors of cardiovascular prognosis in patients with acute coronary syndrome without ST-segment elevation (nSTE-ACS) who underwent percutaneous coronary intervention (PCI).
Material and methods. A 12-month prospective follow-up to assess the occurrence of the combined endpoint (CCT) included 104 nSTE-ACS patients who underwent PCI. The average age of patients is 64 (58–70) years. The concentration of serum glucose, insulin, omentin-1, leptin (LN), lipid spectrum, the level of expression of microRNA-27a, the index of insulin resistance HOMA-IR, the level of tissue protein omentin-1 and LN in the subcutaneous adipose tissue, the thickness of the epicardial (transthoracic echocardiography) and subcutaneous (ultrasound) adipose tissue.
Results. Within 12 months, 39 patients (37,5%) had CCT. When conducting univariate analysis, the potential impact on the risk of CCT in nSTE-ACS patients who underwent PCI was: serum LN concentration more than or equal to 12,71 ng / ml (p = 0, 022), hemodynamically significant stenosis of the left coronary artery (LCA) (p = 0,024), incomplete myocardial revascularization (p = 0, 040), the presence of type 2 diabetes mellitus (p = 0,044), and the serum LN concentration had the highest predictive potential of more than or equal to 12,71 ng / ml (p = 0,007) and the presence of a hemodynamically significant stenosis of LCA (p = 0,002).
Conclusion. During the first 12 months in nSTE-ACS patients who underwent PCI the most significant factors of unfavorable prognosis are hemodynamically significant stenosis of LCA and the serum LN concentration more than or equal to 12,71 ng /ml.