Prevalence of deslipidemia and statins useln Russian Acute Coronary Syndrome Registry

Abstract

Aim. The m of this study was to describe lipid metabolism parameters and prevalence of severe hypercholesterolemia (LDL cholesterol≥5 mmol/l), as well as statin treatment in patients with acute coronary syndrome (ACS) included into Russian ACS registry. Material and methods. 'This is a retrospective study based on datafrom Russian Registry of patients with ACS. Medical records and results of laboratory tests of lipidparameters from 924 patients hospitalisedfor ACS in 2015 were included in the analysis. Results. The registry 2015 population comprised of 60% men, mean age was 65 ± 12years, 27% people were younger than 60 years old. The prevalence of major cardio-vascular risk factors were as follows: arterial hypertension - 85%, hypercholesterolemia - 48%, type 2 diabetes - 17%. The mean levels of key lipid parameters at admission were: total cholesterol-5.2 + 1.4 mmol/L, triglycerides -1.7 ± 1.0 mmol/T, high density lipoprotein cholesterol-1.0 ±0.2 mmol/L, low density lipoprotein (LDL) cholesterol 3.4 + 1.2 mmol/L. The proportion of patients with severe hypercholesterolemia (potentially familial hypercholesterolemia) was 10%. Seventy percent of the 924 subjects included in the analysis had the medical history of cardiovascular disease (CVD), including 29% with documented myocardial infarction. 'Twenty percent of the total number of participants were on statin treatment at the time of admission. This proportion for patients with established CVD reached 30%. Only 9% of patients treated with statins had target level of LDL cholesterol at admission (<1.8 mmol/L). Conclusion. Nearly half of Russian patients hospitalised for ACS has hypercholesterolemia at admission. Severe hypercholesterolemia was found in 10% of patients. Only 1/3 patients with established CVD and thus having class (I) recommendations for statins had the history of statins treatment before admission, and only 9% of them achieved the target level of LDL cholesterol. Urgent actions are needed for improvement of lipid lowering treatment in patients with ACS in Russia.