Relationship of polymorphisms of ace, adra2b, adrb1 and enos genes associated with arterial hypertension and lipid metabolism disorders

Abstract

Purpose. To study the associations of ACE, ADRA2B, ADRB1, MTHFR and eNOS candidate genes of arterial hypertension with lipid metabolisms disorders among the indigenous and non-indigenous population of Mountain Shoria. Materials and methods. We conducted a clinical and epidemiological study of the population who live compactly in the remote areas of Mountain Shoria (Orton, Ust-Kabyrza villages of the Kemerovo region). We examined 1178 inhabitants of the indicated villages by a continuous method, the sampling consisted of adult population (18 years and older).
Results. The prevalence of dyslipidemia while examining the population of Mountain Shoria was 64.8% among the indigenous population and 73.5% among non-indigenous population. Lipid metabolism disorders were detected less frequently in the indigenous ethnic group as compared to the representatives of non-indigenous nationality: hypercholesterolemia – 59.4% vs 66.4%, hyperbetacholesterolemia – 54.1% vs 64.0%, hypoalphacholesterolemia – 23.4% vs 40.1%, hypertriglyceridemia – 23.7% vs 44.8% correspondingly.
Conclusion. In the cohort of the Shors a prognostically unfavorable DD genotype of ADRA2B gene was more frequent and was associated with hypertriglyceridemia. Hypercholesterolemia and hyperbetacholesterolemia are interconnected with DD genotype of АСЕ gene. In the cohort of non-indigenous ethnic group a prognostically unfavorable DD genotypes of ACE gene, ТТ of MTHFR gene were more frequent and were associated with hypoalphacholesterolemia. Hypercholesterolemia, hyperbetacholesterolemia and hypertriglyceridemia are interconnected with DD genotype of ADRA2B gene.