Contents of proinflammatory cytokines, chemoattractants and destructive metalloproteinases in varrious tipe of unstable atherosclerotic plaques
Keywords:
atherosclerotic plaques of coronary arteries, inflammatory-erosive and necrotic types of unstable plaques, inflammatory cytokines, chemoattractants, destructive matrix metalloproteinasesAbstract
Typical and significant inflammatory, destructive biomarkers and chemoattractants of various types of
unstable plaques (lipid type, inflammatory-erosive type, necrotic type) of coronary arteries were determined
and studied in coronary atherosclerosis men without acute coronary syndrome. The increased inflammatory
activity (increased concentrations of interleukin 1-beta, interleukin 6, interleukin 8, interleukin 18 and
monocytes chemotactic protein – 1) was typical not only for unstable plaques inflammatory-erosive type, but
for lipid type too in comparison with necrotic type of unstable plaques. On the other hand, increased destructive
activity (increased levels of tumor necrotic factor alpha, endothelin 1 and decreased level of tissue inhibitor of
metalloproteinase-1) was typical for necrotic type of unstable plaques only