Associations between the level and activity of secretory phospholipase A2 group IIA and the severity of coronary atherosclerosis

Abstract

Aim: To determine the influence of the secretory phospholipase A2 group IIA (sPLA2-IIA) on the severity of
coronary atherosclerosis.
Methods: We studied patients (n = 271), who underwent coronary angiography. They were divided into
3 groups by the number of affected coronary arteries and the control group. Risk factors for cardiovascular
disease, the level and activity of sPLA2-IIA and C-reactive protein (CRP) were determined.
Results: The level of sPLA2-IIA increased with increasing number of affected arteries (p = 0,03). Activity of sPLA2
has tendency to increase with increasing number of affected arteries (p = 0,07). The high density lipoprotein
decreased with increasing degree of coronary atherosclerosis (p = 0,0008), and the level of leukocytes increased
(p = 0,03). CRP level was not significantly different between the groups, but correlated with the concentration of
sPLA2-IIA (r = 0,32).
Conclusion: The increase of the severity of coronary atherosclerosis is associated with a significant increase of
the level of sPLA2-IIA.