Окислительная модификация  липидов и протеинов при остром  инфаркте миокарда

Yu. I. Ragino; E. V.  Sadovski; A. S. Krivchun; V. A. Baum; Ia. V. Polonskaya

Oxidative modification of lipids and proteins in men with coronary atherosclerosis complication

Authors

Yu. I. Ragino Institute of Internal Medicine Siberian Branch of RAMS
E. V. Sadovski Research Institute of Therapy, Siberian Branch of the Russian Academy of Medical Sciences
A. S. Krivchun Research Institute of Therapy, Siberian Branch of the Russian Academy of Medical Sciences
V. A. Baum Research Institute of Therapy, Siberian Branch of the Russian Academy of Medical Sciences
Ia. V. Polonskaya Research Institute of Therapy, Siberian Branch of the Russian Academy of Medical Sciences

Keywords:

smyocardial infarction, oxidized fibrinogen, oxidized low density lipoproteins, hemostasis disturbances, endothelial dysfunction

Abstract

Relationships of lipids and proteins oxidative modifications with disturbances of hemostasis and of endothelial function in coronary atherosclerosis complication – acute myocardial infarction (MI) were studied. The oxidative modification of fibrinogen is 1,7 times higher in acute MI men in comparison with men without coronary heart disease. Increased oxidized fibrinogen level is correlated with increased levels of lipid peroxidation products in plasma and in low density lipoproteins, Willebrand factor, fibrin degradation products, with accelerated leukocyteplatelet aggregation, decreased of plasma NO metabolites level and delayed activity of Hageman-dependent fibrinolysis. Dependent associations of oxidized fibrinogen level with MI and parameters of typical thrombosis and hypercoagulatory hemostasis disturbances and endothelial function were revealed.

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Published

2012-06-29

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Ragino Y. I., Sadovski E. V., Krivchun A. S., Baum V. A., Polonskaya I. V. Oxidative modification of lipids and proteins in men with coronary atherosclerosis complication // The Journal of Atherosclerosis and Dyslipidemias. 2012. VOL. № 2 (7). PP. 27–31.

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No. 2 (7) (2012)

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Oxidative modification of lipids and proteins in men with coronary atherosclerosis complication

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