Клинико-биохимические параметры, ассоциированные с изменением структуры ахиллова сухожилия у мужчин с атеросклерозом

A. V. Anikina; M. E. Amelin; L. V. Shcherbakova; Yu. I. Ragino

doi:10.34687/2219-8202.JAD.2023.01.0004

Authors

A. V. Anikina НИИТПМ-филиал ИЦиГ СО РАН https://orcid.org/0000-0002-9086-6291
M. E. Amelin Research Institute of Internal and Preventive Medicine– branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences(IIPM – Branch of IC&G SB RAS), Novosibirsk, Russia
L. V. Shcherbakova Research Institute of Internal and Preventive Medicine– branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences(IIPM – Branch of IC&G SB RAS), Novosibirsk, Russia
Yu. I. Ragino

DOI:

https://doi.org/10.34687/2219-8202.JAD.2023.01.0004

Keywords:

atherosclerosis, clinical and biochemical parameters, Achilles tendon density, Achilles tendon area, men

Abstract

Summary.

Purpose of the study: To determine the clinical and biochemical parameters associated with changes in the structure of the Achilles tendon in men with atherosclerosis.

Material and methods. 172 men aged 50-70 years with non-coronary atherosclerosis and LDL-C level over 1.8 mmol/L were included. All patients underwent multislice computed tomography angiography (MSCT) of the aorta and its branches and MSCT of the ankle joints to assess changes in the Achilles tendon. The examination included anthropometry, biochemical studies.

Results. In the group with areas of calcium deposition in the structure of the Achilles tendon, age, diastolic pressure, and total blood cholesterol were 1.1 times higher than in the group without deposits. Tendon cross-sectional area, tendon density, low-density lipoprotein cholesterol levels were 1.2 times greater than in the group without calcification areas. Blood calcium levels were also higher in the group with calcium deposits in the tendon. In the group with lipid deposition areas in the structure of the Achilles tendon, the weight was 1.1 times higher, and the area of the tendon section was 1.2 times greater than in the group without lipid deposition areas. In individuals with areas of lipid deposition, the level of total cholesterol was 1.1 times higher than in the group without areas of lipid deposition. The blood phosphorus level was lower in the group with areas of lipid deposition in the tendon. Discussion. Achilles tendinopathy is a common problem, especially in people of working age and also in the elderly. The course of tendinopathy can be aggravated by the presence of pathological areas in the tendon tissue, such as thickening of the tissue (calcification), and areas of decreased density of the tendon tissue (deposition of lipids in the tendon tissue).

Conclusion. In the tissue of the Achilles tendon of men with atherosclerosis, high levels of LDL-C, calcium and phosphorus in the blood, microtrauma can occur at lower loads.

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