Влияние терапии агонистами глюкагоноподобного пептида 1 типа на состояние белой и бурой жировой ткани по данным магнитно-резонансной спектроскопии у пациентов с ожирением

N. S. Kurochkina; S. G. Saakyan; D. N. Nozadze; D. V. Ustyuzhanin; Yu. A. Prus; I. V. Sergienko; M. A. Shariya

doi:10.34687/2219-8202.JAD.2023.01.0003

Authors

N. S. Kurochkina НМИЦ Кардиологии
S. G. Saakyan Federal State Budgetary Institution «National Medical Research Center of Cardiology named after Academian E.I. Chazov» of the Ministry of health of the Russian Federation, Moscow
D. N. Nozadze Federal State Budgetary Institution «National Medical Research Center of Cardiology named after Academian E.I. Chazov» of the Ministry of health of the Russian Federation, Moscow
D. V. Ustyuzhanin Federal State Budgetary Institution «National Medical Research Center of Cardiology named after Academian E.I. Chazov» of the Ministry of health of the Russian Federation, Moscow
Yu. A. Prus Federal State Budgetary Institution «National Medical Research Center of Cardiology named after Academian E.I. Chazov» of the Ministry of health of the Russian Federation, Moscow
I. V. Sergienko Federal State Budgetary Institution «National Medical Research Center of Cardiology named after Academian E.I. Chazov» of the Ministry of health of the Russian Federation, Moscow
M. A. Shariya Federal State Budgetary Institution «National Medical Research Center of Cardiology named after Academian E.I. Chazov» of the Ministry of health of the Russian Federation, Moscow

DOI:

https://doi.org/10.34687/2219-8202.JAD.2023.01.0003

Keywords:

obesity, magnetic resonance spectroscopy, white adipose tissue, brown adipose tissue, GLP-1 agonists

Abstract

The aim – assessment of the ratio of white and brown adipose tissue using magnetic resonance spectroscopy (MRS) in patients with cardiovascular diseases, obesity, diabetes mellitus and the dynamics of changes in the ratio of white and brown adipose tissue before and after GLP-1 agonists treatment.

Material and methods. 72 patients with a body mass index (BMI) over or equal 30 kg/m2 and cardiovascular diseases were included. 27 patients had type 2 diabetes mellitus. The research in dynamic was conducted in 15 patients (MRS initially and after 6 months of therapy). The patients underwent a general clinical assessment, a biochemical blood test, and MRS of the adipose tissue of the supraclavicular region, liver and subcutaneous adipose tissue of the neck. Adipokine levels were measured in all cases.

Results. In obese patients, regardless of both the presence of type 2 diabetes mellitus and the degree of obesity, there was no significant difference in triglyceride levels in adipose tissue, according to the MRS. After 6 months of therapy with GLP-1 agonists, there was a positive trend - decreasing of the volume of adipose tissue in the supraclavicular region - (0.95[0.94; 0.96] versus 0.93[0.91; 0.95] p< 0.001), as well as a significant decrease in the level of triglycerides in the liver (0.13±0.1 versus 0.06±0.04 p<0.01).

Conclusion. This article presents the primary results of influence of GLP-1 agonists therapy on adipose tissue. Our work shows the importance of further investigation of the state of adipose tissue using MRI in a larger number of obese patients and tracking the dynamics of the ratio of white and brown adipose tissue. The disclosure of this mechanism of action of GLP-1 agonists will expand their use in cardiological patients.

Keywords: obesity, magnetic resonance spectroscopy, white adipose tissue, brown adipose tissue, GLP-1 agonists.