Study of resistin level and lipid profile in patients with ST-segment elevation due myocardial infarction, results of one-year follow-up

Abstract

Objective: to study the level of resistin and the lipid profile of patients who underwent STEMI and were obese at the inpatient stage and after 12 months.
Materials and methods: the study included 99 men who had undergone STEMI, with varying degrees of obesity. All patients underwent standard methods of diagnosis and treatment. The lipid profile included the determination of total cholesterol, triglycerides, and high-density lipoprotein cholesterol. The level of low-density lipoprotein cholesterol was calculated according to the standard Friedwald formula: LDL cholesterol (mmol/L) = total cholesterol – HDL-C- triglycerides /2,2. Additionally, waist volume, hip volume, the ratio of waist volume to hip volume, body mass index and the level of human blood resistin were measured.
Results: overweight patients after STEMI have an increased level of blood resistin, which decreases by 1.5 times a year after the index event, but still remains high compared to healthy volunteers. At the hospital stage and a year after STEMI, the level of resistin correlates with the level of OHC and LDL cholesterol, but the relationship weakens. A low percentage of taking high-intensity doses of lipid-modified therapy was revealed, despite the absence of target indicators of the lipid profile.
Conclusion: The data obtained by us allow us to consider resistin as an unfavorable marker of dyslipidemia and metabolic disorders.