Спектр жирных кислот, липидов и маркеров воспаления у больных с коронарным атеросклерозом

Ia. V. Polonskaya; V. S. Shramko; S. V. Morozov; E. I. Chernyak; A. M. Chernyavsky; Yu. I. Ragino

Spectrum of fatty acids, lipids and markers of inflammation in patients with coronary atherosclerosis

Authors

Ia. V. Polonskaya FGBU Research Institute of Therapy and Preventive Medicine of the Siberian Branch of the Russian Academy of Medical Sciences
V. S. Shramko Scientific Institution of Internal and Preventive Medicine
S. V. Morozov N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry Of Siberian Branch of Russian Academy of Sciences
E. I. Chernyak N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry Of Siberian Branch of Russian Academy of Sciences
A. M. Chernyavsky Federal State Budgetary Institution “National Medical Research Center named acad. E. N. Meshalkin” of the Ministry of Health of the Russian Federation
Yu. I. Ragino Scientific Institution of Internal and Preventive Medicine

Abstract

Research purpose. Study of the balance of unsaturatedfatty acids and their associations with indicators of lipid metabolism and markers of inflammation in men with coronary atherosclerosis. Material and Methods. The study included 40 men aged 38-66 years. The basic group - 30 patients with verified coronary angiographic coronary atherosclerosis. The control group included 10 healthy men. In the serum was studiedpalmitoleic (16:1), oleic (18:1), linoleic (18:2 (ω-6)), α-linolenic (18:3 (ω-3)), γ-linolenic (18:3 (ω-6)), arachidonic (20:4 (ω-6)), eicosapentaenoic (20:5 (ω-3)) and docosahexaenoic (22:6 (ω-3)) acids. We calculated the coefficient ω-6/ω-3 polyunsaturated fatty acids. Determined the concentrations of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-Ιβ), interleukin-6 (IL-6), interleukin-8 (IL-8), C-reactiveprotein (CRP), cholesterol, triglycerides, high density lipoproteins (HDL),peroxide oxidation of lipid. Results. In patients with coronary atherosclerosisfound a significant increase in the content of monounsaturated fatty acids - 18.2% (p<0.01), triglyceride, peroxidation products, IL-6, IL-8 and CRP; and decrease in polyunsaturatedfatty acids andHDL. In men with coronary atherosclerosis, the ratio of ω-6/ω-3 polyunsaturated fatty acids was 1.6 times higher (10.9/1 (84.23/7.74); p < 0.05) than in the control group. Correlation analysis revealed multiple relationships between the studied acids; with markers of inflammation -16:1, 18:1 and 18:3 (ω-6); triglycerideslevel- 16:1, 18:1, 18:2, 18:3 (ω-6), 20:5 and 22:6; withcholesterol-16:1, 18:1, 18:2and 18:3 (ω-3). Found a linkpalmitoleic(16:1) and oleic (18:1) with thepresence of coronary atherosclerosis. Conclusion. In coronary atherosclerosis observed pronounced changes infatty acid composition and is accompanied by changes in lipidproflle and markers of inflammation.

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2018-03-26

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Polonskaya I. V., Shramko V. S., Morozov S. V., Chernyak E. I., Chernyavsky A. M., Ragino Y. I. Spectrum of fatty acids, lipids and markers of inflammation in patients with coronary atherosclerosis // The Journal of Atherosclerosis and Dyslipidemias. 2018. VOL. № 1 (30). PP. 32–37.

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Spectrum of fatty acids, lipids and markers of inflammation in patients with coronary atherosclerosis

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