Association of osteopontin level with coronary atherosclerosis and osteoporosis in male patients with stable coronary artery disease

Abstract

Objective: to measure plasma levels of osteopontin inpatients with stable coronary artery disease depending on the severity of osteoporosis, coronary atherosclerosis and coronary artery calcification. Material and Methods. 111 male patients with verified stable coronary artery disease undergoing coronary artery bypass grafting were included in the study. The mean age of the patients was 59.8 (55; 70)years. The inclusion criteria were as follows: age <75years; stable angina І- ІІІ functional class. The exclusion criteria were as follows: severe comorbidities, angina ІV functional class, severe heart failure, prior coronary revascularisation. All patients underwent coronary angiography, multislice computed tomography, densitometry, echocardiography, blood sampling to measure osteopontin levels. Results: 14.4% of patients had single-vessel coronary artery disease (CAD), 24.3%- two-vessel CAD, 61.3%- three-vessel CAD. Mild coronary artery (CA) lesions quantified by the Syntax score were found in 44.2% of patients, moderate- in 30.6% of patients, and severe- in 25.2% of patients. Minor coronary artery calcification (CAC) was detected in 9.9% of patients, mild CAC- in 7.2% of patients, moderate- in 25.2% of patients, severe- in 57.7% of patients. 52.2% of patients had osteopenia, 27.9% of patients- osteoporosis, and 19.8% of patients had normal bone mineral density. Plasma osteopontin levels were 50% higher in patients with the Syntax score above 22 compared to those patients who had the Syntax score below 22 [7.75 (5.14-8.97) vs 5.14 (4.30-7.96) ng/ml, p -0.01]. Ostepontin levels were two times higher inpatients with left ventricular ejectionfraction (LVEF) <40% compared to patients with higher LVEF [8.5 (7.65-10.32) vs. 4.6 (4.48- 7.12),p <0.001]. Osteopontin levels were 48% higher in patients >60years with the Syntax score of >22, than in those with less severe lesions. A direct correlation between ostepontin levels and left ventricular end systolic and diastolic volumes (r- 0.22; p - 0.02; r- 0.21; p - 0.03) and interventricular septum and left ventricular posterior wall (r- 0.24; p - 0.02; r- 0.31; p <0.001) thickness has been identified. Conclusion: osteopontin levels in patients with coronary artery disease correlate with the severity of coronary atherosclerosis,particularly inpatients over60years, as well as with theparameters of left ventricular remodeling.