Factors of inflammation, antioxidant protection and myocardial damage in coronary artery bypass graft in patients with single and multivessel coronary disease

Abstract

Purpose. To estimate the dynamics of factors of inflammation, antioxidant protection and myocardial damage during coronary artery bypass surgery (CABG) in patients with single and multivessel coronary disease.
Methods. Studied were 101 patients who were divided into 2 groups: 1 group comprised 16 patients (68,8% males, mean age 59.1±8.2 years) with single coronary disease, 2 group – 85 patients (80.0% males, mean age 62.2±7.7 years) with multivessel coronary disease. Interleukin – 6 (IL-6), Interleukin – 8 (IL-8), Interleukin – 10 (IL-10), C – reactive protein (CRP), fibrinogen, superoxide dismutase (SOD), troponin I were studied on admission and after operation оn 3.8±1.4 days.
Results. The mean levels of C-reactive protein, interleukin – 8 and interleukin – 10 after CABG increased, but their concentration remained within normal range. Mean interleukin – 6 levels in postoperative period were significantly higher in patients of the 2 group comparing with the 1 group (59,0±29,4 pg/ml vs 34,3±28,2 pg/ml, р=0,03). Superoxide dismutase levels before operation in patients of the both groups were high, but in the 2 group the level of this indicator was significantly higher compared with the patients of the 1 group (3128,0±2286,6 u/g vs 2389,0±1998,7 u/g, р=0,03). After CABG we observed significant lowering of superoxide dismutase levels wherein in patients of the 2 group concentration of this indicator remained higher (1966,9±1635,1 u/g vs 1182,5±965,2 u/g, р=0,03). Troponin I levels increased after CABG in both groups but differences between groups were not significant.
Conclusion. Our work showed significant rising of interleukin – 6 and superoxidedismutase level in early postoperative period, which demonstrated a high activity of factors of inflammation, antioxidant protection and myocardial damage during reconstructive operations. Troponin levels after CABG also rise but the differences between groups are not significant.