The relationship of hormones of adipose tissue with lipid and carbohydrate metabolism in men with coronary atherosclerosis
Keywords:
atherosclerosis, lipid metabolism, carbohydrate metabolism, adipose tissue hormonesAbstract
Objective: to study the relationship between hormones of adipose tissue with lipid and carbohydrate metabolism in patients with atherosclerosis and coronary heart disease.
Materials and methods. The study included 86 men, mean age 60.74±8.1 years with angiographically verified coronary atherosclerosis. All the men had carried out the measurement of blood pressure, waist circumference and thighs, weight and height. All patients had a calculated body mass index. For carrying out biochemical analyses all men once in the morning on an empty stomach was performed blood sampling from a vein to obtain serum. All samples determined the concentration of adiponectin, leptin, resistin, total cholesterol, cholesterol high density lipoprotein (HDL cholesterol), cholesterol low-density lipoprotein (LDL cholesterol), triglycerides (TG), apoliprotein A1 (apoA1), apolipoprotein B (apoВ), lipoprotein (a) (LP(a)), glucose, levels of C-peptide and insulin. Statistical processing of results was carried out in the licensed version of the program SPSS (13.0).
Results. In men with coronary atherosclerosis from the study of complex biomarkers in the blood was elevated resistin,
LDL cholesterol, TG, apoB, LP(a), C-peptide and reduced HDL cholesterol. When examining the relationship of hormones of adipose tissue with lipid and carbohydrate metabolism there was correlation of adiponectin levels with indicators such as leptin, HDL cholesterol, apoA1, insulin and C-peptide; resistin with apoA1, with apoB; leptin with TG and glucose (p<0.01). When studying the relationship of lipid and carbohydrate metabolism have been identified and the relationship of glucose levels with indicators such as HDL cholesterol, LDL cholesterol and TG (p<0.01) and apoB (p<0.05).
Conclusion. The data obtained indicate the relationship of hormones of adipose tissue with lipid, carbohydrate metabolism and the development of coronary atherosclerosis.