The relationship of hormones of adipose tissue with lipid and carbohydrate metabolism in men with coronary atherosclerosis

Authors

  • Ia. V. Polonskaya FGBU Research Institute of Therapy and Preventive Medicine of the Siberian Branch of the Russian Academy of Medical Sciences
  • E. V. Kashtanova Research Institute of therapy and preventive medicine
  • E. M. Stakhneva Research Institute of therapy and preventive medicine
  • A. V. Kurguzov Meshalkin Institute of Circulatory Diseases
  • O. V. Kamenskaya Meshalkin Institute of Circulatory Diseases
  • Yu. I. Ragino Research Institute of therapy and preventive medicine
  • A. M. Chernjavskiy Meshalkin Institute of Circulatory Diseases

Keywords:

atherosclerosis, lipid metabolism, carbohydrate metabolism, adipose tissue hormones

Abstract

Objective: to study the relationship between hormones of adipose tissue with lipid and carbohydrate metabolism in patients with atherosclerosis and coronary heart disease.

Materials and methods. The study included 86 men, mean age 60.74±8.1 years with angiographically verified coronary atherosclerosis. All the men had carried out the measurement of blood pressure, waist circumference and thighs, weight and height. All patients had a calculated body mass index. For carrying out biochemical analyses all men once in the morning on an empty stomach was performed blood sampling from a vein to obtain serum. All samples determined the concentration of adiponectin, leptin, resistin, total cholesterol, cholesterol high density lipoprotein (HDL cholesterol), cholesterol low-density lipoprotein (LDL cholesterol), triglycerides (TG), apoliprotein A1 (apoA1), apolipoprotein B (apoВ), lipoprotein (a) (LP(a)), glucose, levels of C-peptide and insulin. Statistical processing of results was carried out in the licensed version of the program SPSS (13.0).
Results. In men with coronary atherosclerosis from the study of complex biomarkers in the blood was elevated resistin,
LDL cholesterol, TG, apoB, LP(a), C-peptide and reduced HDL cholesterol. When examining the relationship of hormones of adipose tissue with lipid and carbohydrate metabolism there was correlation of adiponectin levels with indicators such as leptin, HDL cholesterol, apoA1, insulin and C-peptide; resistin with apoA1, with apoB; leptin with TG and glucose (p<0.01). When studying the relationship of lipid and carbohydrate metabolism have been identified and the relationship of glucose levels with indicators such as HDL cholesterol, LDL cholesterol and TG (p<0.01) and apoB (p<0.05).
Conclusion. The data obtained indicate the relationship of hormones of adipose tissue with lipid, carbohydrate metabolism and the development of coronary atherosclerosis.

Downloads

Download data is not yet available.

Downloads

Published

2015-12-24

How to Cite

Polonskaya I. V., Kashtanova E. V., Stakhneva E. M., Kurguzov A. V., Kamenskaya O. V., Ragino Y. I., Chernjavskiy A. M. The relationship of hormones of adipose tissue with lipid and carbohydrate metabolism in men with coronary atherosclerosis // The Journal of Atherosclerosis and Dyslipidemias. 2015. VOL. № 4 (21). PP. 46–53.

Issue

No. 4 (21) (2015)

Section

Original research paper

Most read articles by the same author(s)

<< < 1 2