Уровни в крови пропротеиновой  конвертазы субтилизин-кексинового  типа 9 (PCSK 9) при гипери гипохолестеринемии

Yu. I. Ragino; K. S. Astrakova; E. V. Shakhtshneider; E. M. Stakhneva; M. I. Voevoda

Blood levels of proprotein convertase subtilisin/kexin type 9 (pcsk9) in hyper- and hypocholesterolemia

Authors

Yu. I. Ragino Institute of Internal Medicine Siberian Branch of RAMS
K. S. Astrakova Federal State Budgetary Organization “Institute of Internal and Preventive Medicine”
E. V. Shakhtshneider Federal State Budgetary Organization “Institute of Internal and Preventive Medicine”
E. M. Stakhneva Federal State Budgetary Organization “Institute of Internal and Preventive Medicine”
M. I. Voevoda Federal State Budgetary Organization “Institute of Internal and Preventive Medicine”

Keywords:

proprotein convertase subtilisin/kexin type 9, PCSK9, hypercholesterolemia, familial hypercholesterolemia, hypocholesterolemia

Abstract

The aim of the study was to investigate proprotein convertase subtilisin/kexin type 9 (PCSK9) in subjects with hypercholesterolemia (HCH), including familial HCH, and with hypocholesterolemia (population subsamples) and search its associations with blood lipids levels. Blood level of PCSK9 was determined by ELISA using the testsystems «Human ProproteinConvertase 9/PCSK9 Immunoassay» (R&D Systems). It was revealed that in HCH,particularly familial HCH, PCSK9 levels in the blood is higher than in hypocholesterolemia, and higher in women than in men. Histogram distribution of PCSK9 in HCH is a non-parametric nature of a median 223ng/ml. Correlation of PCSK9 with total cholesterol (CH), and especially with CH of low-density lipoprotein (LDL) reflects an important role of this protein in the regulation of metabolism of LDL by affecting the receptors to these particles.

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2015-12-24

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Ragino Y. I., Astrakova K. S., Shakhtshneider E. V., Stakhneva E. M., Voevoda M. I. Blood levels of proprotein convertase subtilisin/kexin type 9 (pcsk9) in hyper- and hypocholesterolemia // The Journal of Atherosclerosis and Dyslipidemias. 2015. VOL. № 4 (21). PP. 15–19.

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Blood levels of proprotein convertase subtilisin/kexin type 9 (pcsk9) in hyper- and hypocholesterolemia

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