The interrelation of the basic parameters of calcium and lipid metabolism with atherosclerosis of the coronary arteries

Abstract

Target. To study the relationship of indicators of calcium and lipid metabolism and assess the effect of these markers on the instability of atherosclerotic foci in the coronary arteries. Materials and methods. The study included 106 men 46-79 years old, who were divided into control (without coronary heart disease (IHD) and the main group with angiographically verified coronary atherosclerosis. The main group was divided into two subgroups. The first group included 36 men in whom only stable men were found, in the second - 40 men who had unstable atherosclerotic plaques in the coronary arteries. (TG), alkaline phosphatose, calcium, magnesium and phosphorus Statistical processing of the results was carried out in the licensed version of the SPSS program (13.0). Results. In men of the main group, the levels of calcium (2.4 ± 0.0 mmol / l}, magnesium (0.8 ± 0.0 mmol / l), calcitonin (2.2 + 0.7 pg / ml) alkaline phosphatase were found to be higher. (165.9 ± 4.5 U / L) u TG (177.6 ± 15.0 mg / dl), lower HDL cholesterol level (34.5 + 1.2 mg / dl). At the same time, changes in LDL cholesterol and calcitonin levels are associated with the presence of unstable atherosclerotic plaques in the coronary arteries.Study of the content of total cholesterol in the blood serum did not give statistically significant differences between the study groups.Correlation analysis revealed a relationship between total cholesterol and calcium (r = 0.402, p = 0.004), LDL cholesterol (r = 0.771 , p = 0.001) and TG (r = 0.262, p = 0.02); calcium with LDL cholesterol (r = 0.380, p = 0.004). The relationship of phosphorus level with TG (r = 0.436, p = 0.001) and with HDL cholesterol (r = -0.280, p = 0.03); alkaline phosphatase with magnesium (r = 0.331, p = 0.006). The level of calcitonia depended on TT (r = 0.433, p = 0.02) and LDL cholesterol (r = 0.442, p = 0.02); there was a dependence (r = -0.682, p = 0.001) of calcitonin on HDL cholesterol. Conclusion. The data obtained indicate a relationship between lipid and calcium metabolism indicators with the development of coronary atherosclerosis and the possibility of destabilization of atherosclerotic foci.