Relationship of blood osteonectin concentration with inflammatory, oxidative and lipid biomarkers in coronary atherosclerosis and its complications

Abstract

Aim. The studying the blood osteonectin concentration in coronary atherosclerosis and its complications, and its associations with key atherosclerosis biomarkers.
Materials and methods. Concentrations of stromal stem cells protein-marker osteonectin were studied with help of proteome technology «PureProteome Protein A and Protein G Magnetic Beads» by direct method of biomagnetic protein separation with magnetic microspheres in 42 men with coronary atherosclerosis (CA) with coronary heart disease (CHD) with stable angina pectoris II–IV FC, in 20 men with acute myocardial infarction (MI) and in 45 age control men without CHD.

Results. Concentrations of blood osteonectin were higher in men with CA and stable angina pectoris (up to 2.7-fold, p<0.01) and in men with MI (up to 3.0-fold, p<0.01) in comparison with control group men. Significant correlations (p<0.05) of blood osteonectin with some key biomarkers of atherosclerosis (lipid, inflammatory and oxidative) and with CA were revealed.
Conclusion. These results indicate that osteonectin as marker of stromal stem cells with osteogenous potential, probably, plays important role in atherogenesis and is one of the new biomarkers of CA and its complications.