Relationship of low densities lipoprotein subfractions with triglycerides level in patients with different grade of coronary arteries stenosis

Abstract

Aim. To determine relationship of low-density lipoprotein (LDL) subfractional profile in patients with normal and elevated triglyceride (TG) levels with different grade of coronary arteries stenosis.
Materials and methods. Patients aged 18-80 years who underwent invasive coronary angiography (n=267; 176 male, 91 female) were included in the study. LDL subfractions were separated and measured using «Lipoprint LDL System».
Results. Patients were divided into two groups according to the degree of coronary artery stenosis: 0-20% or > 70%. Positive correlation between TG levels and LDL3 and LDL4 portions was found: r=0.35, р<0.0001 and r=0.25, р<0.0001, respectively. In patients with increased TG levels, irrespectively of coronary arteries stenosis degree, portion of VLDL, IDLC and LDL2 were increased, while portions of IDLA and LDL1 were decreased. Higher portion of small dense pro-atherogenic LDL3 and LDL4 together with elevated TG levels were found only in patients with severe atherosclerosis detected.
Conclusion. The combination of elevated TG levels with higher portion of small dense LDL particles might be regarded as an additional risk factor and/or marker of severe atherosclerosis.