The diagnostic value of adhesive molecules sICAM -1 and sVCAM-1 in ischemic heart disease

Abstract

Ischemic heart disease (IHD) is associated with chronic inflammation as usual. The role of a number of non-specific inflammatory markers (CRP, fibrinogen and others) in atherosclerosis pathogenesis has been described in details. On the early stages atherosclerotic inflammation stimulates monocytes adhesion to activated endothelial cells due to over expression of adhesion cell molecules on cellular membranes. The increased serum levels of soluble forms of these molecules (sICAM-1, sVCAM-1) are revealed in many diseases, including acute coronary syndrome and chronic heart failure. The data of a number of studies, in witch these serum markers were determined in patients with different forms of IHD are presented in this article.
Conclusion. sICAM-1 and sVCAM-1 may be used as additional laboratory markers for the evaluation of the severity of inflammation in different IHD forms.