Interleukin-6 and high density lipoprotein cholesterol levels association with atherosclerotic lesions severity in coronary arteries

Abstract

Aim. To determine the association between cardiovascular disease risk factors and presence of coronary arteries lesions with the involvement of left main coronary artery (LMCA).
Methods. We included male and female patients 40-60 years old, who underwent coronary angiography: with coronary atherosclerosis and LMCA involvement – group 1 (n=83), with coronary atherosclerosis without any lesions in LMCA – group 2 (n=88), and patients with intact coronary arteries – group 3 (n=34). All patients identified Cardiovascular disease traditional risk factors as well as lipoprotein (a), interleukin-6, C-reactive protein serum levels were determined in all patients.
Results. A percent of women was higher in group 3 compare to group 1 and group 2 (59% vs 17% p=0.00001 and 59% vs 16% p=0.00001, respectively), as well as a percent of smokers was lower (19% vs 44% p=0.03 and 19% vs 61% p=0.0001, respectively), as was expected. All patients were treated with hypolipidemic therapy, however the levels of high density lipoprotein was significantly lower in the group 1 compare to group 2 and group 3 (1.04±0.29 vs 1.2±0.49, p=0.04 and 1.04±0.29 vs 1.28±0.35, p=0.005, respectively). The levels of lipoprotein (a) were not significantly different between the groups. Serum interleukin-6 had a tendency to increase in the group 1 versus group 3 (4.31±5.24 vs 2.06±1.8, p=0.06, respectively).