The development of atherosclerosis and its complications in patients with high levels of c triglycerides or low HDL

Abstract

The aim of this work is to demonstrate patients with dyslipidemia (DLP) and atherosclerosis who have a high level of blood triglycerides (TG) or a very low content of antiatherogenic high density lipoproteins (HDL) in the absence of hyperlipidemia (HLP).
Material and methods. There were examined 30 patients with hypertriglyceridemia (HTG) who had TG level >4,0 mmol/l and 25 patients with a low HDL content (<0,90 mmol/l) in the absence of HLP. In all cases blood lipid spectrum was examined twice. Clinical investigation was aimed at the revealing of atherosclerosis in different vascular beds.
Results. 30 patients with HTG (average age 47 years old) were divided into two groups: 20 persons with TG level=15,2 ± 2,4 mmol/l and clinical manifestations of atherosclerosis and 10 persons with TG level=19,0 ± 3,8 mmol/l without clinical manifestations of atherosclerosis. All 25 patients with a low HDL content (0,76 ± 0,02 mmol/l) and average age of 46 years old had atherosclerosis of coronary or cerebral vessels although they had not HLP as itself. The data show that a complicated atherosclerosis can develop
mainly in men after 40-45 years of age not only with hypercholesterolemia but also with other dyslipidemic states.