The role of sortilin in atherosclerosis and carbohydrate metabolism disorders (literature review)
DOI:
https://doi.org/10.34687/2219-8202.JAD.2024.02.0003Abstract
Cardiovascular disease is a global health, social and economic problem. Currently, there is an active search for new biological markers and therapeutic targets in order to develop effective approaches to risk stratification and secondary prevention of cardiovascular pathology. Researchers are interested in sortilin, which belongs to the family of vacuolar sorting receptors type I. Sortilin takes part in intracellular transport between the endoplasmic reticulum, Golgi apparatus, lysosomes and the plasma membrane, thereby regulating many biological processes. The purpose of the presented article was to analyze studies devoted to the study of sortilin as a biomarker in atherosclerosis and carbohydrate metabolism disorders. According to the data obtained to date, sortilin is a promising molecule with diagnostic and prognostic potential for atherosclerosis and carbohydrate metabolism disorders. Further studies examining sortilin as an additional laboratory tool are needed. Regulating the concentration and expression of sortilin may be a promising strategy for treating people with lipid and carbohydrate metabolism disorders.
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Copyright (c) 2024 А. М. Алиева, Н. В. Теплова, И. Е. Байкова, А. М. Рахаев, И. А. Ковтюх, И. В. Котикова, И. Г. Никитин
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