Баланс жирных кислот в крови и бляшках у пациентов с каротидным атеросклерозом

A. V. Tarasov; A. G. Kochetov; D. M. Galyautdinov; A. V. Ershov; V. V. Grechenko; K. V. Troyanov; V. P. Massenko

doi:10.34687/2219-8202.JAD.2024.01.0007

Authors

A. V. Tarasov Chazov National Medical Research Center of Cardiology
A. G. Kochetov Chazov National Medical Research Center of Cardiology
D. M. Galyautdinov Chazov National Medical Research Center of Cardiology
A. V. Ershov Chazov National Medical Research Center of Cardiology
V. V. Grechenko Pirogov Russian National Research Medical University
K. V. Troyanov Pirogov Russian National Research Medical University
V. P. Massenko Chazov National Medical Research Center of Cardiology

DOI:

https://doi.org/10.34687/2219-8202.JAD.2024.01.0007

Keywords:

carotid atherosclerosis, fatty acids, fatty acid balance

Abstract

AIM. The study of the balance of fatty acids in the blood and carotid plaques in patients with carotid atherosclerosis.

Materials and methods. There were enrolled 27 patients with carotid atherosclerosis, including 22 males and 5 females. The average age of the patients was 67.3 ± 4.9 years. Blood samples were collected from the ulnar vein. Surgically-obtained carotid plaq+ue specimens were generally removed en bloc within the media. 28 fatty acids were studied in the blood serum and carotid atherosclerotic plaques. Descriptive statistics of measures of the central tendency are represented by the mean and median with a 95% confidence interval, as well as the mode.

Results and discussion. Plaque concentrations of most fatty acids were statistically significantly higher than those in blood. The tendency of greater accumulation of fatty acids in plaques with lower values in the blood relative to other fatty acids was revealed. In blood, only palmitic and stearic fatty acid levels fell outside the known reference intervals. The contents of fatty acids relative to each other in the blood and plaques differed quantitatively, but for most fatty acids their proportionality remained, except for erucic, gondoic, palmitoleic, oleic, and linoleic fatty acids.

Conclusion. In carotid atherosclerosis, there is a different balance of fatty acids in the blood and carotid atherosclerotic plaques, independent of fatty acid blood concentrations relative to established reference intervals. Unlike other fatty acids, the contents of erucic, gondoic, palmitoleic, oleic, and linoleic fatty acids compared to other fatty acids are higher in the blood than in plaques.

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