Влияние компонентов системы интерлейкина-6 на тяжесть поражения коронарных артерий

Yu. A. Shuvalova; S. A. Moskalenko; A. I. Kaminnyi

doi:10.34687/2219-8202.JAD.2022.03.0006

Authors

Yu. A. Shuvalova
S. A. Moskalenko
A. I. Kaminnyi

DOI:

https://doi.org/10.34687/2219-8202.JAD.2022.03.0006

Keywords:

Interleukin-6; soluble IL-6 receptor; soluble glycoprotein gp130; severity of atherosclerosis, index GensiniScore

Abstract

Objective: To carry out a comprehensive assessment of the interaction between inierleukin-6 (IL-6) system components and the severity of atherosclerotic coronary lesions.

Materials and Methods: 479 patients who underwent coronary angiography were included in the study. Plasma levels of IL-6, soluble IL-6 receptor and soluble glycoprotein 130 (sgp130) were determined by ELISA. The severity of coronary atherosclerosis was determined by the number of affected arteries and the GensiniScore index.

Results: IL-6 levels increased significantly with increasing number of coronary arteries affected (2.04 (1.54;3.5) vs 3.13 (1.28;4.78) vs 3.65 (1.86;7.32) vs 3.51 (2.09;7.25) pg/ml, respectively; p=0.002), soluble IL-6 receptor levels were not significantly different and sgp130 levels were significantly decreased (361 (332-390) vs 340 (308-371) vs 301 (275-328) vs 314 (289-338) ng/mL, p=0.009). There was a weak positive correlation of the GensiniScore index with IL-6 levels (r=0.15, p=0.04) and a moderate negative correlation with sgp130 levels (r= -0.24, p<0.002). No association of GensiniScore index with IL-6 level was found in linear regression analysis (β = 0.12; B = 0.86; p = 0, 12). We obtained an association of the GensiniScore index with sgp130 levels (β = -0.19; B = -0.12; p = 0.01), which remained statistically significant by multivariate analysis after adjustment for sex, age, smoking status, arterial hypertension, type 2 diabetes and high-density lipoprotein cholesterol (β = -0.17; B = -0.10; p = 0.03), but the association of sgp130 with the GensiniScore becomes statistically insignificant (β = -0.20; B = -0.12; p = 0.06) when these factors as well as IL-6 and sgp130 are included in the analysis.

Conclusions: Our results suggest that sgp130 levels have a more pronounced effect on coronary atherosclerosis severity than IL-6 levels, with sgp130 levels appearing to be an important additional risk factor for coronary atherosclerotic lesion severity without being an independent predictor.

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