Analysis of the concentration of lipoprotein(a) in clinical practice: relevance and unsolved issues

Abstract

Elevated level of lipoprotein(a) [Lp(a)] is the most common genetic disorder of lipid metabolism associated with early manifestation of atherosclerosis and atherothrombosis, as well as with the development of aortic stenosis in an old age.
In 2019 European Society of Cardiology in cooperation with the European Society of Atherosclerosis recommended to evaluate the concentration of Lp(a) once for each adult patient, so this test has become rather popular.
The article highlights current recommendations for measuring the concentration of Lp(a). The standardization of methods for quantitative determination of Lp(a) and harmonization of measurements are considered, which will allow clinicians to interpret correctly the results to assess cardiovascular risk and the effectiveness of lipid-lowering therap