Contribution of polymorphisms of genes of the Interleukin-6 system to the development of atherosclerosis

Abstract

Coronary artery disease continues to be a high morbidity and mortality rate. Its prevention is expected to be the main goal of health policy. The risk of developing coronary heart disease is associated with a complex interaction of genetic factors, environmental factors, and lifestyle. Over the past decade, significant progress has been made in understanding the genetic architecture of this disease. In this article we are trying to provide knowledge about genetic coronary heart disease, in particular, about the Interleukin-6 system and its role to development of coronary heart disease.