Роль системы интерлейкина-6  в развитии атеросклероза

S. A. Moskalenko; Yu. A. Shuvalova; A. I. Kaminnyi

doi:10.34687/2219-8202.JAD.2020.02.0001

Authors

S. A. Moskalenko National Medical Research Center of Cardiology of the Ministry of Health of Russian Federation
Yu. A. Shuvalova National Medical Research Center of Cardiology of the Ministry of Health of Russian Federation
A. I. Kaminnyi National Medical Research Center of Cardiology of the Ministry of Health of Russian Federation

DOI:

https://doi.org/10.34687/2219-8202.JAD.2020.02.0001

Keywords:

cytokine, Inflammation, receptor – IL-6R, sIL-6R, signal transduction-gp130, trans-signaling, atherosclerosis, sgp130

Abstract

The inflammatory theory of the development of atherosclerosis is relevant. A number of studies have shown that the development of atherosclerosis is associated with circulating inflammatory markers. IL-6 is elevated in patients with coronary heart disease and may be a marker of inflammation associated with cardiovascular risk. At the same time, the fact of the presence of both pro-inflammatory and atherogenic and protective properties of IL-6 is generally recognized. Recently, the study of this cytokine and its effect on the cell has revealed the presence of a complex system – IL-6/IL-6R/gp130, through which the effect of IL-6 is realized. This article describes the biological role of IL-6 and systematizes the results of currently
available clinical studies.