Oxidized low-density lipoproteins as indicators of the developmnet of chronic cardiovascular insufficiency in patients with chronic obstructive pulmonary disease of occupational etiology

Abstract

Aim. Detection and evaluation of oxidized low-density lipoproteins (ox-LDL) circulating in the blood in patients with occupational chronic obstructive pulmonary disease (occupational COPD), establishment of ox-LDL communication with concomitant cardiovascular pathology.
Materials and methods. The patients with occupational COPD were divided into two groups: group 1 (n=73, 42 men and 31 women) – patients with occupational COPD and AH, group 2 (n=35, 26 men and 9 women) – patients with occupational COPD, AH and CHD (stable effort angina of the 2nd and 3rd grade). The comparison group consisted of healthy individuals (n=16). The amount of ox-LDL in serum was determined by the method of solid phase enzyme-linked immunosorbent assay (ELISA) using a commercial reagent kit “MDA-oxLDL” from the company “Biomedica Gruppe” (Austria). The level of highly sensitive CRP was determined by ELISA using a set of reagents from the “Vector-Best” company (Russia). The concentrations of cholesterol (Chol), low-density lipoproteins (LDL-Chol), high-density lipoproteins (HDL-Chol) and triglycerides (TG) were determined using reagent kits of “Thermo Fisher Scientific Oy” (Finland).
Results and conclusion. The research has shown that the ox-LDL in the blood is found in 80% of patients in stable occupational COPD. With complication of comorbid cardiovascular pathology, the quantity of ox-LDL in serum increases, exceeding the maximum level in 50% of the observed patients with occupational COPD without cardiovascular pathology and in combination with HT of the 1st degree. Ox-LDL can be used as a criterion for monitoring the development of cardiovascular pathology in occupational COPD. It is possible that their increase in the serum of patients with occupational COPD may be a sign of a complicated course of comorbid cardiovascular diseases.