The influence of magnesium orotate on the morphological and functional state of arteries in smoking and non-smoking postmenopausal women

Abstract

The aim. To reveal the effect of magnesium orotate on the morphofunctional state of the vascular wall in healthy smokers and non-smokers in postmenopausal women.
Materials and methods. The study included 75 women of practically healthy women, (average age 51.4 ± 4.3 years), who are in postmenopause about 2.5 years. The women who were included in the study were divided into 2 groups (1 group consisted of 40 women smokers, group 2 – 35 non-smokers), received magnesium orotate for 12 weeks at a daily dose of 2 g. Initial and after a 12-week course of treatment with magnesium. All participants of the study conducted orotomized ultrasound Doppler sonography of the carotid and brachial arteries with the determination of blood flow indicators, intima-media complex thickness, endothelium-dependent vasodilation, as well as simultaneous monitoring of oscillometric blood flow indicators method.
Results. The study showed a positive effect of magnesium orotate on the morphofunctional state of arterial walls in postmenopausal women, which was manifested by improved endothelial function, decreased intima-media complex thickness, pulse wave velocity, rigidity indices, general peripheral vascular resistance, increased brachial artery compliance, with more pronounced positive shifts in the group of non-smoking women.
Conclusion. The results of the study indicate the effectiveness of magnesium orotate in slowing the development of morphofunctional changes, improving endothelial function and maintaining the elasticity of the arteries in postmenopausal women.