Inkretine and adipokine state among young and middle-aged men with initial atherosclerosis

Abstract

Objective: to determine the peculiarities of inkretine and adipokine state in relation to lipid-carbohydrate metabolism among young and middle-aged men with initial atherosclerosis of the carotid arteries. Material and methods: have been examined 530 men 38.5±5.6 years old; 448 (80%) of them were men of young age (from 30 to 44 years), 82 (20%) person – middle-aged (from 45 to 55 years old). All the patients have been divided into 2 groups: 1st – 106 men with ultrasonic characteristics of primary atherosclerosis of common carotid arteries; 2nd – 424 men without changes of the vascular wall. Have been evaluated lipidogram, glucose tolerance test, investigated the levels of adipokines and inkretines to determine the metabolic changes.
Results: intima-media thickness in patients with initial atherosclerosis was 1.2±0.3 mm, in 2nd group – 0.65±0.1 mm respectively (p < 0.001). Arterial hypertension was found from 69% (1st) vs 33% (2nd group) of men (χ2 =43.9; p < 0.001); abdominal obesity – 63 vs 43% (χ2 =12.9; p<0.001). Dyslipidemia was diagnosed in 60% of men in 1st group and 30% of the patients 2nd group (χ2=19.4; p<0.001). The frequency of prediabetes and early postload hyperglycemia in 1st and 2nd groups amounted to 39 vs 28% (p>0.05) and 63 vs 43% (χ2 =5.6; p=0.017); he combination of dyslipidemia and prediabetes – 27 vs 15% (p>0.05); dyslipidemia and the early postload hyperglycemia – 48 vs 19% of patients (χ2 =14.4; p < 0.001), respectively. In patients with initial atherosclerosis determined maximum values of leptin, IL-6 and TNF-α. Was defined as a stable positive relationship of atherosclerosis, disorders of lipid and carbohydrate spectrum with leptin concentration.
Conclusion: the level of serum leptin should be used as an additional marker of defeat of the cardiovascular system
and the initial atherosclerosis in patients with abdominal obesity