Indicators of lipid metabolism in the inhabitants of Mountain Shoria: ethnic peculiarities and the impact of living conditions

Abstract

Purpose. To assess the differences in lipid metabolism indicators among the inhabitants of Mountain Shoria, estimated in the periods 1998-2002 and 2012-2015. Materials and methods. The research of lipid metabolism indicators was performed in two stages (stage 1 - 1998-2002, stage 2 - 2012-2015) in the areas of compact settlement of the Shors. We examined 1215 and 572 inhabitants correspondingly. All the inhabitants were divided by the age groups. Statistical data processing was carried out using STATISTICA 10.0. Results. At all the time stages of the research it was found out that in general men and women of both nationalities showed an increase in manifestations of lipid metabolism disorders along with the age increase. In the period 1998-2002 the levels of total cholesterol, triglycerides and low-density lipoprotein cholesterol (LDL cholesterol) in the elder age groups showed their national differences, represented by more atherogenic shifts in the representatives of non-Shor group. However LDL cholesterol level was less associated with age than other lipids. During the second phase of the study (2012-2015) it was found that the degree of ethnic differences was decreased. The differences in the indicators of total cholesterol and LDL cholesterol, observed in 2000, were not revealed in any of the age groups regardless of gender during the second stage of the research. In the dynamics of 15-year period, it should be noted that the least favourable changes were revealed inyoung and middle-aged people: both the Shors and non-Shor people of both genders showed the increase in mean values of total cholesterol, LDL cholesterol and the decrease in high density lipoprotein cholesterol concentration. But, this tendency is the most pronounced in the group of indigenous women. Conclusion. During all research periods of the research (1998-2002 and 2012-2015) the prevalence of lipid metabolism disorders in the indigenous population of Mountain Shoria both in women and in men was lower than that in non-indigenous population. Over the past 15 years, the inhabitants of this region showed the atherogenic change in lipid profile, in a greater degree in indigenous population.