Association of classic risk factors for cardiovascular disease with the severity of coronary atherosclerosis

Abstract

Objective: our aim was to investigate the association of the maximum number of significant risk /factors for cardiovascular disease, lipid /parameters and inflammatory /parameters with the severity of coronary atherosclerosis. Methods: a total of 314 patients were included, which diagnostic coronary angiography was performed. The severity of coronary lesions was assessed by the number of affected arteries and the index of Gensini score. Determination of the levels of biochemical/parameters was carried out by E/LISA method. Results: direct association was identified between the number of affected arteries and the gender (r² = 0.32; p = 0.0000001), smoking (r² = 0.19; p = 0.0007), glucose levels (r² = 0.12; p = 0.04) and inverse correlation with HDL cholesterol levels (HDL-C) (r² = -0.27; p = 0.00006). These parameters have shown an association with the index of Gensini score: gender (r² = 0.34; p - 0.0000001), smoking (r² = 0.20; p - 0.0007), glucose levels (r² - 0.13,p - 0.03), the level of HDL-C (r² = -0.31, p = 0.000004). Also direct correlation wasfound of Gensini score index with age (r² = 0.15,p - 0.01 ) and family history (r² = 0.12, p - 0.047). Conclusion: the association between the gender, age, smoking, family history, level of HDL-C, glucose levels, and the severity of coronary atherosclerosis was detected. The role of lipoprotein (a) is less significant in the severity “ of coronary atherosclerosis, but, nevertheless, it needs further refinement.