The relationship between myeloid dendritic cells CC chemokine CCL17 concentrations with the severity of coronary atherosclerosis.

Abstract

Aim. The study explored the association between circulating myeloid dendritic cells and chemokine CCL17 with the severity of coronary atherosclerosis and the presence of hemodynamically significant stenoses of the coronary arteries. The effects of the inflammatory response, which occurs in response to the implantation of a coronary stent, in the levels of CCL17 and MDC were also evaluated. Materials and Methods. The study involved 82 male patients, who underwent coronary angiography and 10 heathy individuals. Vatients were divided into 4 groups based on the severity of coronary atherosclerosis. In addition, all patients were divided into 2 groups according to the presence of hemodynamically significant stenoses of the coronary arteries. The severity of atherosclerotic coronary lesions was evaluated using the Gensini score. All patients underwent determination of circulating myeloid dendritic cells in the peripheral blood by flow cytometry, chemokine CCL17 by quantitative Sandwich ELISA. Results. No significant relationships between the levels in blood myeloid dendritic cells and chemokines CCL17 with severity of coronary atherosclerosis were identified. CHD patients with hemodynamically significant stenoses of the coronary arteries were characterised by lower levels of myeloid dendritic cells.