The relationship of hormones of adipose tissue with inflammatory markers and homocysteine in coronary atherosclerosis

Abstract

Research purpose. To study the relationship of hormones of adipose tissue with inflammatory markers and homocysteine in coronary atherosclerosis. Material and methods. The study included 92 men aged 46–79 years with verified coronary angiographic coronary atherosclerosis. In the serum was determined the concentrations of adiponectin, leptin, resistin, tumor necrosis factor α (TNFα), interleukin 1β (IL1β), interleukin 6 (IL6), interleukin 8 (IL8), C-reactive protein (CRP), homocysteine. The activity of processes of lipid peroxidation in isolated from the serum the low-density lipoproteins (LDL) was determined by the concentration of malondialdehyde (MDA).
Results. IIn men with coronary atherosclerosis, the concentration of adiponectin in blood was 9,04±0,92 mg/ml, resistin was 8.3±0.58 ng/ml. the level of leptin was increased – 20,64±3,69 ng/ml Direct correlation with the body mass index was identified for leptin (p<0.01).
Correlations were also found between resistin and CRP (r=0,520, p<0.01), resistin and IL (r=0,324, p<0.05), resistin and the initial level of malonic dialdehyde (r=0,401, p<0.01). The average levels of key proinflammatory cytokines interleukin 6 and interleukin 8 were elevated, 11,73±2,01 PG/ml and of 8.79±1,07 PG/ml, respectively. The level of products of malonic aldehyde in the blood was significantly elevated, compared with the average population values.
Conclusions. In the case of coronary atherosclerosis detected elevated concentrations of the major markers of inflammatory activity (IL, IL, PSA, MDA). The content of adipose tissue hormones adiponectin and resistin corresponds to normal values, and the level of leptin is elevated. Direct correlation between leptin and the degree of oxidative stress between resistin and PSA, resistin and IL, resistin, and baseline levels of MDA.