Pregnancy-Associated Plasma Protein A - Analyzer of Atherosclerotic Plaque Instability in Acute Coronary Syndrome

Abstract

Aim. To analyze the levels of pregnancy-associated plasma protein A in blood plasma in patients with acute coronary syndrome. Comparative analysis of a pregnancy-associated plasma protein-A with markers of necrosis and acute phase of inflammation in acute coronary syndrome. Clinical and prognostic value of a pregnancy-associated plasma protein A in acute coronary syndrome. Material and methods. Determining the concentration of pregnany associated plasma protein A in 44 patients with acute myocardial infarction, 27 patients with unstable angina, as well as in the comparison group and control. In 71patients of the study group of markers of necrosis and acute inflammation phase, blood lipids. Results. Concentrations of pregnancy-associated plasma protein A was significantly higher in the acute coronary disease compared with healthy individuals, patients with hypertension, coronary heart disease. Comparative analysis of a pregnancy-associated plasma protein A and markers of necrosis, acute phase showed that the levels of pregnancy-associated plasma protein A positively correlated with troponin have similar curves of restenosis in the beginning of the second day of the disease. Daily mortality accompanied by high levels of pregnancy associated plasma protein A, massive vascular inflammation. Relatively favorable factors daily mortality in the study were the high levels of pregnancy-associated plasma protein-A, necrosis markers troponin and lactate dehydrogenase fraction 1 as outcome measures in myocardial infarction, but with preservation of organ function of the heart. Conclusions. Pregnancy-associated plasma protein A - a new highly sensitive biochemical marker of intravascular atherosclerotic plaque damage. The present study shows that the levels of pregnancy-associated plasma protein A in correlation with markers of necrosis and acute phase should be applied in patients with acute coronary disease and have a clinical-prognostic value in the flrst hours of clinical attacks.