Impact of metabolic syndrome and its components on long-term prognosis in patients with acute ST-segment elevation myocardial infarction

Abstract

Study Objective: To assess the effects of metabolic syndrome and its components on long-term prognosis in atients with acute ST-segmentelevation myocardial infarction (STEMI). Material and Methods. The study included 112 patients, 76 of whom had metabolic syndrome. The duration of the study follow-up period was 36 months. The study endpoints were death from any cause and major adverse cardiovascular events (MACE): death, recurrent myocardial infarction, and re-hospitalization for worsening of the patient's condition. Study Results. The rates of MACE and death in patients with metabolic syndrome, were higher than that in the control group: 74.0% vs. 30.0%, p-0.027 and 34.5% vs. 8.3%, p-0.031, respectively. Metabolic syndrome and all its components significantly increased the risk of MACE. Metabolic syndrome and only two of its components - obesity and impaired glucose tolerance - were associated with increased risk of death. In patients with acute myocardial infarction, metabolic syndrome was an independent predictor of both death and MACE. Obesity, impaired glucose tolerance and increased low-density lipoprotein cholesterol (TDT-C) and triglycerides (TG) levels were independent predictors of MACE. Obesity and impaired glucose tolerance were also independent predictors of death. Conclusion. Metabolic syndrome, obesity and impaired glucose tolerance are independent risk factors for MACE and death in patients with metabolic syndrome and acute STEMI Although elevated TDT-C and TG levels don't - affect the death rates, they actas independent risk factors for MACE in this group of patients.