The role of markers of lipoproteins oxidative metabolism in determining the long-term prognosis in patients with acute coronary syndrome without ST segment elevation

Abstract

Aim. To examine the relationship of oxidative metabolism of lipoproteins markers with the development of adverse outcomes in non-ST-Elevation Acute Coronary Syndromes (NSTE-ACS) during one year of follow-up. Methods and Materials. A total of 159 patients with NSTE-ACS have been included in the study. The average age of patients was 61.0+9.19 years. Among the patients studied was 61% of men and 39% women. Determination of oxidised low-density lipoprotein (ох-LDL) and antibodies to ох-LDL serum in all patients was fulfilled by the 10th day of hospitalisation. Follow-up was 12+4 months for the study group. All patients were divided into two groups: with a favorable (n-123) and unfavorable (n-35) outcomes (death from cardiovascular causes, unstable angina (UA), myocardial infarction (MI)). Results. The ox-LDL level in serum was significantly higher in patients with unfavorable outcome. It was found that increased levels of ox-LDL more than 2.4 mkg/ml increases the risk of an unfavorable outcome for the year in patients with NSTE-ACS more than 10 times (OR=10.4, 95% Cl: 2.38-45.7; p<0.0001). The differences in the levels of antibodies to ox-LDL in the groups were not found. Conclusion. The elevated levels of ox-LDL more than 2.4 mkg/ml in hospital period can be laboratory markers of adverseprognosis inpatients with NSTE-ACS.