Pluronic F-127-induced experimental dyslipidemia as a model for the revealing of a connecting link between immune response regulation and cholesterol metabolism

Authors

  • N. N. Volsky Research Institute of Fundamental and Clinical Immunology
  • O. M. Perminova Research Institute of Fundamental and Clinical Immunology
  • O. P. Kolesnikova Research Institute of Fundamental and Clinical Immunology

Keywords:

cholesterol, immune reactions, pluronic F127, poloxamer 407, graft versus host reaction, GvHR, Th1/Th2-balance, nuclear receptors LXR

Abstract

Aim. Abundant clinical and experimental evidences show that varied immunopathological processes are associated with disturbed cholesterol metabolism. The mechanism of this link is still understood incompletely and invites further investigation.
Results. It was demonstrated that pluronic F-127 (poloxamer 407)-induced dyslipidemia in mice is accompanied by the shift of Th1/Th2-balance which affects the intensity of immune reactions.
Conclusion. It was concluded that the administration of pluronic F-127 to animals is usable as an adequate laboratory model for the revealing of a connecting link between immune response regulation and cholesterol metabolism. The hypothetical mechanism of this connection involving the modulation of liver X receptors activity is discussed.

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Published

2015-09-29

How to Cite

Volsky N. N., Perminova O. M., Kolesnikova O. P. Pluronic F-127-induced experimental dyslipidemia as a model for the revealing of a connecting link between immune response regulation and cholesterol metabolism // The Journal of Atherosclerosis and Dyslipidemias. 2015. VOL. № 3 (20). PP. 34–43.

Issue

No. 3 (20) (2015)

Section

Original research paper