Содержание провоспалительных  цитокинов, хемоаттрактанов  и деструктивных металлопротеиназ  в разных типах нестабильных  атеросклеротических бляшек

Yu. I. Ragino; A. M. Chernyavski; Ya. V.  Polonskaya; A. M. Volkov; E. V. Kashtanova

Contents of proinflammatory cytokines, chemoattractants and destructive metalloproteinases in varrious tipe of unstable atherosclerotic plaques

Authors

Yu. I. Ragino Institute of Internal Medicine Siberian Branch of RAMS
A. M. Chernyavski – Research State of Circulation Pathology of Russian Medical Technology Agency
Ya. V. Polonskaya Institute of Internal Medicine Siberian Branch of RAMS
A. M. Volkov Research State of Circulation Pathology of Russian Medical Technology Agency
E. V. Kashtanova Institute of Internal Medicine Siberian Branch of RAMS

Keywords:

atherosclerotic plaques of coronary arteries, inflammatory-erosive and necrotic types of unstable plaques, inflammatory cytokines, chemoattractants, destructive matrix metalloproteinases

Abstract

Typical and significant inflammatory, destructive biomarkers and chemoattractants of various types of
unstable plaques (lipid type, inflammatory-erosive type, necrotic type) of coronary arteries were determined
and studied in coronary atherosclerosis men without acute coronary syndrome. The increased inflammatory
activity (increased concentrations of interleukin 1-beta, interleukin 6, interleukin 8, interleukin 18 and
monocytes chemotactic protein – 1) was typical not only for unstable plaques inflammatory-erosive type, but
for lipid type too in comparison with necrotic type of unstable plaques. On the other hand, increased destructive
activity (increased levels of tumor necrotic factor alpha, endothelin 1 and decreased level of tissue inhibitor of
metalloproteinase-1) was typical for necrotic type of unstable plaques only

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2011-03-30

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Ragino Y. I., Chernyavski A. M., Polonskaya Y. V., Volkov A. M., Kashtanova E. V. Contents of proinflammatory cytokines, chemoattractants and destructive metalloproteinases in varrious tipe of unstable atherosclerotic plaques // The Journal of Atherosclerosis and Dyslipidemias. 2011. VOL. № 1 (2). PP. 23–27.

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Contents of proinflammatory cytokines, chemoattractants and destructive metalloproteinases in varrious tipe of unstable atherosclerotic plaques

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