Optimization of hemostasis indicators under the influence of statin therapy in patients with ischemic heart diseases

Abstract

Purpose. To evaluate the influence of statin therapy on hemostatic indicators in patients with coronary heart disease.
Methods. 168 patients with ischemic heart disease (mean age 56.7±4.3 years) were included. We evaluated hemostatic parameters (fibrinogen, D-dimer, interval beginning of ADP-induced platelet aggregation) and endothelial function (von Willebrand factor).
Results. The 24 weeks period of simvastatin 40 mg daily, atorvastatin 55 mg daily and rosuvastatin 20 mg daily reduces of von Willebrand factor and fibrinogen levels (p<0.05). Simvastatin had no significant effect on D-dimer concentration while atorvastatin and rosuvastatin therapy resulted in decreasing of this indicator. Rosuvastatin increases interval to the beginning of ADP-induced platelet aggregation (р<0.05) during 24 weeks.
Conclusion. Long term statin therapy reduces the severity of endothelial dysfunction and trombogenic potential of the blood.